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Sleep,
fat, and the mysteries of leptin
Leptin is a hormone that helps to regulate weight. It usually works
like a safety valve. The more fat tissue you have, the more leptin
you produce, which tells your body to eat less and expend more energy.
Of the whole obese population, though, only 5 percent have congenital
abnormalities that cause low leptin production. Many obese people
have very high leptin levels but have developed resistance to this
hormone, so their bodies don’t hear the message it gives.
. . . The adverse effects of high leptin levels on cardiovascular
function remain, however, even when the body has developed resistance
to
the fat-reducing effect.
Leptin resistance also correlates with obstructive sleep apnea,
a
problem in which people stop breathing while they sleep. We had
something of a clinical gestalt in our lab. Many people with sleep
apnea came in saying they had put on significant weight in the preceding
year . . . . It turns out that treating sleep apnea lowers leptin
levels and seems to decrease body fat also. The bottom line is there’s
a relation among sleep apnea, leptin, and visceral fat that needs
to be better understood.
—Virend Somers, Professor of Medicine at the Mayo Clinic,
in his talk on "Obesity, Leptin, and Cardiovascular Disease,"
sponsored by the Vascular Biology Seminar Series on September 15,
2003
Scripted religions
Most religions are scripted. Even if it’s the Whole Earth
Catalog, you have to have something to refer to.
—Martin E. Marty, Robert W. Woodruff Visiting Professor
of Interdisciplinary Religious Studies, in a talk sponsored by the
Center for the Interdisciplinary Study of Religion, on September
8, 2003
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