Positions and Honors    |   Editorial Boards |   Selected Peer-Reviewed Publications

Position Title: Chief of Division of Neuroscience at Yerkes National Primate Research Center, Candler Professor of Neuropharmacology, and Georgia Research Alliance Eminent Scholar, Emory University.

Education/Training:

Positions and Employment:

American Association for the Advancement of Science (1969-present). 

Society for Neuroscience (1973-present; Nominating Committee, 1984-1987; Presidential Symposium 
Speaker, 1990; Public Information Committee, 1996-1999; Social Issues Committee, 2003-2006;  
President, Atlanta Chapter, 2003-2004). 

American Society for Neurochemistry (1973-1983; Program Committee, 1978;). 

American Society for Pharmacology and Experimental Therapeutics (1974-present; Symposium          Organizer at International Meeting, 1984; Selection Committee for Otto Krayer Award, 1993, 1997, 2002;    and Neuropharmacology Division Executive Committee, 2002-2005, and Chair, 2003-2004; John Jacob Abel Award Committee, 2004-2007; Council, 2005-2007). 

Mid-Atlantic Acetylcholine Discussion Group (1973-1978; Co-Chairman, 1975). 

American College of Neuropsychopharmacology (Scientific Associate, 1978; Member, 1980; Fellow 1986-present; Member of Education and Training Committee, 1984-1987; Program Committee, 1988-1990; Ethics Committee, 1991-1993; Credentials Committee, 1993-1995; Animals in Research Committee, 2001-2004). 

International Brain Research Organization (IBRO) (1979-present). 

International Drug Abuse Research Society (IDARS) (Member 2004; President, 2004-2007). 

College on Problems of Drug Dependence, Inc. (Member, 1994; Board of Directors, 1994-1998;                 Executive Committee, 1999-2001; President, 1999-2000; Nominating Committee, 1994-1995;      Publications Committee, 1994-1995; Media Relations Committee, Chair, 1994-1997; Long-Range Planning Committee, 2001-2004; Media Committee, 2001-2007; ONDCP Task Force, 2001-2003). 

Neuroethics Society (2007 – present). 

Professional Honors and Other Experience:

Phi Beta Kappa (1970) 
National Institute of Mental Health Research Career Development Award, Type II (3/1/75 - renewed 3/1/80 and 3/1/85) 
National Institute of Mental Health Small Grants Committee (9/1/77-8/31/81) 
Distinguished Young Scientist in Maryland Award (1977; The Maryland Academy of Sciences) 
Visiting Scientist, National Institute for Medical Research, Mill Hill, London (Summer 1978; Molecular 
     Pharmacology Unit, A.S.V. Burgen, Director) 
Consultant, Pharmacology Department, Hoffman-La Roche, 1980-1985 
Grass Traveling Scientist, Spring 1981, to Halifax, Nova Scotia 
Listed among "1,000 Contemporary Scientists Most Cited 1965-1978", Current Contents 24, 5, 1981 
Daniel H. Efron Award (1984, from the American College of Neuropsychopharmacology) 
Mathilde Solowey Award for Research in Neuroscience, (1985 from the Foundation for Advanced  
     Education in the Sciences) 
First Ariens Lecture (1985, The Dutch Pharmacological Society; DUPHAR) 
Family Therapy Institute of Washington, DC, Part-time Family Therapy Training, 1983-1985. 
     Jay Haley and Cloe Madanes, Supervisors. 276 individual and group supervision hours. 
Graduate Certificate in Substance Abuse Counseling, 1988, Loyola University 
Sterling Lecture (1987, Tufts Univ. School of Medicine; 1988, University of Kentucky Medical School) 
Gold Lecture on Substance Abuse (1988, University of Florida Medical School at Gainesville) 
Senior Executive Service Appointment (November 20, 1988, Dept. of Health & Human Services) 
Administrator's Award for Meritorious Achievement (1989, ADAMHA) 
Upjohn Lecture (1989, Uniformed Services University of the Health Sciences) 
Thomas L. O'Donohue Memorial Lecture (1989, Howard University) 
A. Ross McIntyre Award (1990, University of Nebraska Medical Center) 
Presidential Symposium Lecturer (1990, Society for Neuroscience) 
First Ivan F.W. Davidson Memorial Lecture (1990, Bowman Gray School of Medicine) 
Distinguished Lecturer (1992, Stritch School of Medicine) 
Otto Krayer Award (1992, American Society for Pharmacology and Experimental Therapeutics) 
Harry Williams Lectureship Award (1992, Emory University School of Medicine) 
Grass Lecture (1993, University of Kansas, MO) 
Boots Distinguished Neuroscientist Lecture (1993, Louisiana State University Medical Center) 
Visiting Committee, Medical Department (1993-1997), Brookhaven National Laboratory. 
Consultant, Guilford Pharmaceuticals (1995) 
Charles Howard Candler Professor (1995, Emory University) 
Distinguished Lecturer (1996, University of South Alabama) 
Eminent Scholar Award (1996, State of Georgia and Emory University) 
The Dana Alliance, Member (1997-) 
Advisory Board, Addiction Studies Institute, Wake Forest University (1999-) 
President, College on Problems of Drug Dependence, Inc. (1999-2000) 
Scientific Advisory Board, Amethyst Technologies (1999-2000) 
Scientific Advisory Board, Addiction Therapies, Inc. (1999-2003) 
NIDA K05 Senior Scientist Award (1999-2004; 2004-2008) 
NIDA Special Emphasis Panels (1999-2004) 
Listed (by ISI) among the 250 most cited scientists in Neuroscience from 1981-2000 (rank 23rd) 
Scientific Advisory Board, Center for Psychiatric Neuroscience, University of Mississippi Medical School          (2000-2005) 
NIDA K Study Section (Ad hoc, 2003-2004; regular member, 2004-2008) 
Board of Directors, Aptotec, Inc. (2004-) 
International Drug Abuse Research Society (IDARS) [a founding member (2004) and first 
     President (2004-2007)] 
External Advisory Board, Center of Research Excellence in Natural Products Neuroscience, 
     University of Mississippi at Oxford (2006-2010).

Wendy and Stanley Marsh Lecture in Substance Abuse and Addictive Disorders, Texas Tech University                Health Sciences Center, 2007

Citations “h” index = 103, “m”  index = 2.71 (in 2007).

Fulbright Award for Chile, South America (2008).

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Editorial Boards (past and present):

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SELECTED PEER-REVIEWED PUBLICATIONS  
(from more than 900 total publications, including refereed papers, chapters, abstracts, edited books, and patents):

Kuhar, M.J. and Aghajanian, G.K.  Selective Accumulation of 3H-Serotonin by Nerve Terminals of Raphe Neurones: An autoradiographic Study.  Nature 241: 187-189, 1973.

Kuhar, M.J., Sethy, V.H., Roth, R.H., and Aghajanian, G.K. Choline: Selective Accumulation by Central Cholinergic Neurons.  J. Neurochem. 20: 581-593, 1973.

Kuhar, M.J. and Yamamura, H.I.  Light Autoradiographic Localization of Cholinergic Muscarinic Receptors in Rat Brain by Specific Binding of a Potent Antagonist.  Nature 253: 560-561, 1975.

Simon, J.R. and Kuhar, M.J.  Impulse-Flow Regulation of High Affinity Choline Uptake in Brain Cholinergic Nerve Terminals.  Nature (London.) 255: 162-163, 1975.

Uhl, G.R., Kuhar, M.J., and Snyder, S.H.  Neurotensin: Immunohisto-chemical Localization in Rat Central Nervous System.  Proc. Natl. Acad. Sci. (USA) 74: 4059-4063, 1977.

Young, W.S., III, and Kuhar, M.J.  Autoradiographic Localization of Benzodiazepine Receptors in the Brain of Humans and Animals.  Nature 280: 393-395, 1979.

Palacios, J.M., Young, W.S., III, and Kuhar, M.J.  Autoradiographic Localization of Gamma-aminobutyric (GABA) Receptors in Rat Cerebellum.  Proc. Natl. Acad. Sci. (USA) 77: 670-674, 1980.

Palacios, J.M. and Kuhar, M.J.  Beta-adrenergic Receptor Localization by Light Microscopic Autoradiography. Science 208: 1378-1380, 1980.

Zarbin, M.A., Wamsley, J.K., and Kuhar, M.J.  Axonal Transport of Muscarinic Cholinergic Receptors in Rat Vagus Nerve: High and Low Affinity Agonist Receptors Move in Opposite Directions and Differ in Nucleotide Sensitivity.  J. Neurosci. 2: 934-941, 1982.

Wagner, Jr., H.N., Burns, H.D., Dannals, R.F., Wong, D.F., Langstrom, B., Duelfer, T., Frost, J.J., Ravert, H.T., Links, J.M., Rosenbloom, S.B., Lukas, S.E., Kramer A.V., and Kuhar, M.J.  Imaging Dopamine Receptors in the Human Brain by Positron Tomography.  Science 221(4617): 1264-1266, 1983.

Uhl, G.R. and Kuhar, M.J.  Chronic Neuroleptic Treatment Enhances Neurotensin Receptor Binding in Human and Rat Substantia Nigra.  Nature 309: 350-352, 1984.

Wong, D.F., Wagner, H.N., Jr., Dannals, R.F., Links, J.M., Frost, J.J., Ravert, H.T., Wilson, A.A., Rosenbaum, A.E., Gjedde, A., Douglass, K.H., Petronis, J.D., Folstein, M.F., Thomas Toung, J.K., Burns H.D., and Kuhar, M.J. Effects of Age on Dopamine and Serotonin Receptors Measured by Positron Tomography in the Living Human Brain.  Science 226: 1393-1396, 1984.

Wong, D.F., Wagner, H.N., Jr., Dannals, R.F., Links, J.M., Kuhar, M.J., and Gjedde, A.  Human Brain Receptor Distribution.  Science 232: 1269-1271, 1986.

De Souza, E.B., Whitehouse, P.J., Kuhar, M.J., Price, D.L., and Vale, W.W.  Reciprocal Changes in Corticotropin-Releasing Factor (CRF)-Like Immunoreactivity and CRF Receptors in Cerebral Cortex of Alzheimer's Disease.  Nature 319: 593-595, 1986.

Wong, D.F., Wagner, H.N., Jr., Tune, L.E., Dannals, R.F., Pearlson, G.D., Links, J.M., Tamminga, C.A.,Broussolle, E.P., Ravert, H.T., Wilson, A.A., Thomas Toung, J.K., Malat, J., Williams, J.A., O'Tuama, L.A. Snyder, S.H., Kuhar, M.J., and Gjedde, A.  Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics.  Science 234: 1558-1563, 1986.

Ritz, M.C., Lamb, R.J., Goldberg S.R., and Kuhar, M.J.  Cocaine Receptors on Dopamine Transporters are Related to Self-administration of Cocaine.  Science 237: 1219-1223, 1987.

Grigoriadis, D.E., Wilson, A.A., Lew, R., Sharkey, J.S., and Kuhar, M.J.  Dopamine Transport Sites Selectively Labeled by a Novel Photoaffinity Probe: 125I-DEEP.  J. Neurosci. 9(8): 2664-2670, 1989.

Kuhar, M.J., Sanchez-Roa, P.M., Wong, D.F., Dannals, R.F., Grigoriadis, D.E., Lew, R., and Milberger, M. Dopamine Transporter: Biochemistry, Pharmacology and Imaging.  Eur. Neurol. 30(1): 15-20, 1990.

Carroll, F.I., Lewin, A.H., Philip, A., Parham, K., Boja, J.W., and Kuhar, M.J.   Synthesis and Ligand Binding of Cocaine Isomers at the Cocaine Receptor.  J. Med. Chem. 34: 883-886, 1991.

Kuhar, M.J., Lloyd, D.G., and Loats, H.L.  Imaging Receptors by Autoradiography: Computer-Assisted Approaches.  J. Chem. Neuroanat. 4: 319-327, 1991.

Volkow, N.D., Gatley, S.J. Fowler, J.S., Chen, R., Logan, J., Dewey, S.L., Ding, Y.-S., Pappas, N., King, P., MacGregor, R.R., Kuhar, M.J., Carroll, F.I. and Wolf, A.P. Long-Lasting Inhibition of in vivo Cocaine Binding to Dopamine Transporters by 3(-(4-Iodophenyl)Tropane-2-Carboxylic Acid Methyl Ester: RTI-55 or (CIT. Synapse 19(3): 206-211, 1995.

Ding. Y.-S., Gatley, S.J., Fowler, J.S., Volkow, N.D., Aggarwal, D., Logan, J., Dewey, S.L., Liang, F., Carroll, F.I. and Kuhar, M.J.  Mapping Nicotinic Acetylcholine Receptors with PET.  Synapse 24: 403-407, 1996.

Wong, D.F., Harris, J.C., Naidu, S., Yokoi, F., Marenco, S., Dannals, R.F., Ravert, H.T., Yaster, M., Evans, A., Rousset, O., Bryan, R.N., Gjedde, A., Kuhar, M.J. and Breese, G.R.   Dopamine Transporters are Markedly Reduced in Lesch-Nyhan Disease in vivo.  Proc. Natl. Acad. Sci. USA 93: 5539-5543, 1996.

Nirenberg, M.J., Chan, J., Pohorille, A., Vaughan, R.A., Uhl, G.R., Kuhar, M.J. and Pickel, V.M.  The Dopamine Transporter: Comparative Ultrastructure of Dopaminergic Axons in Limbic and Motor Compartments of the Nucleus Accumbens.  J. Neurosci. 17: 6899-6907, 1997.

Koylu, E.O., Couceyro, P.R., Lambert, P.D., Ling, N.C., DeSouza, E.B., and Kuhar, M.J.  Immunohistochemical Localization of Novel CART Peptides in Rat Hypothalamus, Pituitary and Adrenal Gland.  J. Neuroendocrinol. 9: 823-833, 1997.

Molina, P.E., Ding, Y.-S., Carroll, F.I., Liang, F., Volkow, N.D., Pappas, N., Kuhar, M., Abumrad, N., Gatley, S.J., and Fowler, J.S.  Fluoro-norchloroepibatidine: Preclinical Assessment of Acute Toxicity. Nucl. Med. Biol. 24:743-747, 1997.

Lambert, P.D., Couceyro, P.R., McGirr, K.M., Dall Vechia, S.E., Smith, Y., and Kuhar, M.J.  CART Peptides in the Central Control of Feeding and Interactions with Neuropeptide Y.  Synapse 29: 293-298, 1998.

Kuhar, M. Neurotransmitter Transporters are NOT in the Synapse?  Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, December 7-16th.  Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/simantov/kuhar0153/two.html, 1998.

Broberger, C., Holmberg, K., Kuhar, M.J., and Hökfelt, T.  Cocaine- and Amphetamine-Regulated Transcript in the Rat Vagus Nerve: A Putative Mediator of Cholecystokinin-Induced Satiety.  Proc. Natl. Acad. Sci. USA 96: 13506-13511, 1999.

Dall Vechia-Adams, S., Smith, Y., and Kuhar, M.J.  CART Peptide-Immunoreactive Projection from the Nucleus Accumbens Targets Substantia Nigra Pars Reticulata Neurons in the Rat.  J. Comp. Neurol. 434: 29-39, 2001.

Kuhar, M.J., Carroll, F.I., Bharat, N., and Landry, D.W. Anticocaine Catalytic Antibodies Have No Affinity for RTI Compounds: Implications for Treatment.  Synapse 41: 176-178, 2001.

Kuhar, M.J. and Joyce, A.R.  Slow Onset of CNS Drugs: Can Changes in Protein Concentration Account for the Delay?  Trends Pharmacol. Sci. 22: 450-456, 2001.

Jaworski, J.N., Kozel, M.A., Philpot, K.B., and Kuhar M.J.  Intra-accumbal Injection of CART (Cocaine-Amphetamine Regulated Transcript) Peptide Reduces Cocaine-Induced Locomotor Activity.  J. Pharmacol. Exp. Ther. 307: 1038-1044, 2003.

Dominguez, G., del Giudice, E.M., and Kuhar, M.J.  CART Peptide Levels are Altered by a Mutation Associated with Obesity at Codon 34. Mol. Psychiatry 9: 1065-1066, 2004.

Vicentic, A., Lakatos, A., and Kuhar, M.J.  CART (Cocaine- and Amphetamine-Regulated Transcript) Peptide Receptors:  Specific Binding in AtT20 Cells.  Eur. J. Pharm. 528: 188-189, 2005.

Philpot, K.B., Dallvechia-Adams, S., Smith, Y., and Kuhar, M.J. A Cocaine-and Amphetamine-Regulated-Transcript Peptide Projection from the Lateral Hypothalamus to the Ventral Tegmental Area.  Neuroscience 135: 915-925, 2005.

Vicentic, A., Francis, D., Moffett, M., Lakatos, A., Rogge, G., Hubert, G.W., Harley, J., and Kuhar, M.J. Maternal Separation Alters Serotonergic Transporer Densities and Serotonergic 1A Receptors in Rat Brain. Neuroscience 140: 355-365, 2006.

Moffett, M.C., Harley, J., Francis, D., Sanghani, S.P., Davis, W.I., and Kuhar, M.J. Maternal Separation and Handling Affects Cocaine Self-administration in Both the Treated Pups as Adult and the Dams. J. Pharmaol. Exp. Ther. 317: 1210-1218, 2006.

Jones, DC and Kuhar, MJ. Cocaine-amphetamine-regulated transcript expression in the rat nucleus accumbens is regulated by adenylyl cyclase and the cyclic adenosine 5'-monophosphate/protein kinase a second messenger system.  J Pharmacol Exp Ther. 2006 Apr;317(1):454-61.  PMID 16322355.

Carroll, F.I., Howard, J.L., Howell, L.L., Fox, B.S., and Kuhar, M.J. Development of the Dopamine Transporter Selective RTI-336 as a Pharmacotherapy for Cocaine Abuse. AAPS J. 8: E196-E203, 2006.

Jones DC, Kuhar MJ.  CART receptor binding in primary cell cultures of the rat nucleus accumbens. Synapse. Feb;62(2):122-7. 2008. PMID 18000808.

Jaworski JN, Hansen ST, Kuhar MJ, Mark GP.  Injection of CART peptide into the nucleus accumbens reduces cocaine self-administration in the rat.  Behav Brain Res 2008 191:266-271.  PMID: 18485497. 

Hubert GW and Kuhar MJ.  Cocaine administration increases the fraction of CART cells in the rat nucleus
accumbens that co-immunostain for c-Fos.  Neuropeptides 42:339-43, 2008.  PMID18314190. 

Rogge, G., Jones, D., Hubert, G.W., Lin, Y.  CART peptides: regulators of body weight, reward and other functions.  Nat Rev Neurosci, 2008 9(10):747-58.  PMID: 18802445. 

Kuhar, M.J.  On Blacklisting in Science.  Sci Eng Ethics 14:301-303, 2008.  PMID 18668347 

Rogge GA, Jones DC, Green T, Nestler E, and Kuhar MJ.  Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo.  Brain Res 1251:42-52, 2009.  PMID 19046951. 
 
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