Societies:
American Association for the Advancement of Science
(1969-present).
Society for Neuroscience (1973-present;
Nominating Committee, 1984-1987; Presidential Symposium
Speaker, 1990; Public Information Committee, 1996-1999; Social Issues
Committee, 2003-2006;
President, Atlanta Chapter, 2003-2004).
American Society for Neurochemistry (1973-1983;
Program Committee, 1978;).
American Society for Pharmacology and Experimental
Therapeutics (1974-present; Symposium Organizer
at International Meeting, 1984; Selection Committee for
Otto Krayer Award, 1993, 1997, 2002; and Neuropharmacology
Division Executive Committee, 2002-2005, and Chair, 2003-2004;
John Jacob Abel Award Committee, 2004-2007; Council, 2005-2007).
Mid-Atlantic Acetylcholine Discussion Group (1973-1978;
Co-Chairman, 1975).
American College of Neuropsychopharmacology (Scientific
Associate, 1978; Member, 1980; Fellow 1986-present; Member
of Education and Training Committee, 1984-1987; Program
Committee, 1988-1990; Ethics Committee, 1991-1993; Credentials
Committee, 1993-1995; Animals in Research Committee, 2001-2004).
International Brain Research Organization (IBRO)
(1979-present).
International Drug Abuse Research Society
(IDARS) (Member 2004; President, 2004-2007).
College on Problems of Drug Dependence, Inc.
(Member, 1994; Board of Directors, 1994-1998;
Executive Committee, 1999-2001; President, 1999-2000;
Nominating Committee, 1994-1995; Publications Committee,
1994-1995; Media Relations Committee, Chair, 1994-1997;
Long-Range Planning Committee, 2001-2004; Media Committee,
2001-2007; ONDCP Task Force, 2001-2003). Neuroethics Society (2007 – present).
Professional Honors and Other Experience:
Phi Beta Kappa (1970)
National Institute of Mental Health Research Career Development Award,
Type II (3/1/75 - renewed 3/1/80 and 3/1/85)
National Institute of Mental Health Small Grants Committee (9/1/77-8/31/81)
Distinguished Young Scientist in Maryland Award (1977; The Maryland
Academy of Sciences)
Visiting Scientist, National Institute for Medical Research, Mill Hill,
London (Summer 1978; Molecular
Pharmacology Unit, A.S.V. Burgen, Director)
Consultant, Pharmacology Department, Hoffman-La Roche, 1980-1985
Grass Traveling Scientist, Spring 1981, to Halifax, Nova Scotia
Listed among "1,000 Contemporary Scientists Most Cited 1965-1978",
Current Contents 24, 5, 1981
Daniel H. Efron Award (1984, from the American College of Neuropsychopharmacology)
Mathilde Solowey Award for Research in Neuroscience, (1985 from the
Foundation for Advanced
Education in the Sciences)
First Ariens Lecture (1985, The Dutch Pharmacological Society; DUPHAR)
Family Therapy Institute of Washington, DC, Part-time Family Therapy
Training, 1983-1985.
Jay Haley and Cloe Madanes, Supervisors. 276
individual and group supervision hours.
Graduate Certificate in Substance Abuse Counseling, 1988, Loyola University
Sterling Lecture (1987, Tufts Univ. School of Medicine; 1988, University
of Kentucky Medical School)
Gold Lecture on Substance Abuse (1988, University of Florida Medical
School at Gainesville)
Senior Executive Service Appointment (November 20, 1988, Dept. of Health
& Human Services)
Administrator's Award for Meritorious Achievement (1989, ADAMHA)
Upjohn Lecture (1989, Uniformed Services University of the Health Sciences)
Thomas L. O'Donohue Memorial Lecture (1989, Howard University)
A. Ross McIntyre Award (1990, University of Nebraska Medical Center)
Presidential Symposium Lecturer (1990, Society for Neuroscience)
First Ivan F.W. Davidson Memorial Lecture (1990, Bowman Gray School
of Medicine)
Distinguished Lecturer (1992, Stritch School of Medicine)
Otto Krayer Award (1992, American Society for Pharmacology and Experimental
Therapeutics)
Harry Williams Lectureship Award (1992, Emory University School of Medicine)
Grass Lecture (1993, University of Kansas, MO)
Boots Distinguished Neuroscientist Lecture (1993, Louisiana State University
Medical Center)
Visiting Committee, Medical Department (1993-1997), Brookhaven National
Laboratory.
Consultant, Guilford Pharmaceuticals (1995)
Charles Howard Candler Professor (1995, Emory University)
Distinguished Lecturer (1996, University of South Alabama)
Eminent Scholar Award (1996, State of Georgia and Emory University)
The Dana Alliance, Member (1997-)
Advisory Board, Addiction Studies Institute, Wake Forest University
(1999-)
President, College on Problems of Drug Dependence, Inc. (1999-2000)
Scientific Advisory Board, Amethyst Technologies (1999-2000)
Scientific Advisory Board, Addiction Therapies, Inc. (1999-2003)
NIDA K05 Senior Scientist Award (1999-2004; 2004-2008)
NIDA Special Emphasis Panels (1999-2004)
Listed (by ISI) among the 250 most cited scientists in Neuroscience
from 1981-2000 (rank 23rd)
Scientific Advisory Board, Center for Psychiatric Neuroscience, University
of Mississippi Medical School
(2000-2005)
NIDA K Study Section (Ad hoc, 2003-2004; regular member, 2004-2008)
Board of Directors, Aptotec, Inc. (2004-)
International Drug Abuse Research Society (IDARS) [a founding member
(2004) and first
President (2004-2007)]
External Advisory Board, Center of Research Excellence in Natural Products
Neuroscience,
University of Mississippi at Oxford (2006-2010).
Wendy and Stanley Marsh Lecture in Substance
Abuse and Addictive Disorders, Texas Tech University
Health Sciences Center, 2007
Citations “h” index
= 103, “m” index = 2.71 (in 2007).
Fulbright Award for Chile,
South America (2008).
Back
to top
Editorial
Boards (past and present):
Biochemical Pharmacology
Brain Research
Current Opinion in Central and Peripheral Nervous Systems
Current Protocols in Pharmacology
Drug and Alcohol Dependence
Experimental and Clinical Psychopharmacology
International Journal of Molecular Medicine
Journal of Chemical Neuroanatomy
Journal of Neurochemistry
Journal of Neuroscience
Journal of Pharmacology and Experimental Therapeutics
Life Sciences
Medical Hypotheses and Research
Molecular and Cellular Neuroscience
Neurobiology of Aging
NeuroImage
Neuropeptides
Neuropharmacology
Neuropsychopharmacology
Neuroscience-Net
Peptide Research
Research Communications in Substances of Abuse
Substance and Alcohol Misuse
Synapse
Trends in Neuroscience |
(2004-present)
(1980-1989)
(1998-2000)
(1996-2001)
(1995-2001)
(1992-2000)
(1997-present)
(1987-2000)
(1980-1985)
(1983-1989)
(1993-2006)
(2003-present)
(2003-present)
(1990-1995)
(1980-1985)
(1991-1995)
(1980-present)
(1980-1992)
(1991-1995)
(1996-present)
(1989-1994)
(1991-1995)
(1980-1985)
(1992-present)
(1982-1994) |
Back
to top
SELECTED
PEER-REVIEWED PUBLICATIONS
(from more than 900 total publications, including refereed papers, chapters,
abstracts, edited books, and patents):
Kuhar, M.J. and Aghajanian, G.K. Selective
Accumulation of 3H-Serotonin by Nerve Terminals of Raphe Neurones: An
autoradiographic Study. Nature 241: 187-189, 1973.
Kuhar, M.J., Sethy, V.H., Roth, R.H.,
and Aghajanian, G.K. Choline: Selective Accumulation by Central Cholinergic
Neurons. J. Neurochem. 20: 581-593, 1973.
Kuhar, M.J. and Yamamura, H.I. Light
Autoradiographic Localization of Cholinergic Muscarinic Receptors in
Rat Brain by Specific Binding of a Potent Antagonist. Nature 253: 560-561,
1975.
Simon, J.R. and Kuhar, M.J. Impulse-Flow
Regulation of High Affinity Choline Uptake in Brain Cholinergic Nerve
Terminals. Nature (London.) 255: 162-163, 1975.
Uhl, G.R., Kuhar, M.J., and Snyder, S.H.
Neurotensin: Immunohisto-chemical Localization in Rat Central Nervous
System. Proc. Natl. Acad. Sci. (USA) 74: 4059-4063, 1977.
Young, W.S., III, and Kuhar, M.J. Autoradiographic
Localization of Benzodiazepine Receptors in the Brain of Humans and
Animals. Nature 280: 393-395, 1979.
Palacios, J.M., Young, W.S., III, and
Kuhar, M.J. Autoradiographic Localization of Gamma-aminobutyric (GABA)
Receptors in Rat Cerebellum. Proc. Natl. Acad. Sci. (USA) 77: 670-674,
1980.
Palacios, J.M. and Kuhar, M.J. Beta-adrenergic
Receptor Localization by Light Microscopic Autoradiography. Science
208: 1378-1380, 1980.
Zarbin, M.A., Wamsley, J.K., and Kuhar,
M.J. Axonal Transport of Muscarinic Cholinergic Receptors in Rat Vagus
Nerve: High and Low Affinity Agonist Receptors Move in Opposite Directions
and Differ in Nucleotide Sensitivity. J. Neurosci. 2: 934-941, 1982.
Wagner, Jr., H.N., Burns, H.D., Dannals,
R.F., Wong, D.F., Langstrom, B., Duelfer, T., Frost, J.J., Ravert, H.T.,
Links, J.M., Rosenbloom, S.B., Lukas, S.E., Kramer A.V., and Kuhar,
M.J. Imaging Dopamine Receptors in the Human Brain by Positron Tomography.
Science 221(4617): 1264-1266, 1983.
Uhl, G.R. and Kuhar, M.J. Chronic Neuroleptic
Treatment Enhances Neurotensin Receptor Binding in Human and Rat Substantia
Nigra. Nature 309: 350-352, 1984.
Wong, D.F., Wagner, H.N., Jr., Dannals,
R.F., Links, J.M., Frost, J.J., Ravert, H.T., Wilson, A.A., Rosenbaum,
A.E., Gjedde, A., Douglass, K.H., Petronis, J.D., Folstein, M.F., Thomas
Toung, J.K., Burns H.D., and Kuhar, M.J. Effects of Age on Dopamine
and Serotonin Receptors Measured by Positron Tomography in the Living
Human Brain. Science 226: 1393-1396, 1984.
Wong, D.F., Wagner, H.N., Jr., Dannals,
R.F., Links, J.M., Kuhar, M.J., and Gjedde, A. Human Brain Receptor Distribution.
Science 232: 1269-1271, 1986.
De Souza, E.B., Whitehouse, P.J., Kuhar,
M.J., Price, D.L., and Vale, W.W. Reciprocal Changes in Corticotropin-Releasing
Factor (CRF)-Like Immunoreactivity and CRF Receptors in Cerebral Cortex
of Alzheimer's Disease. Nature 319: 593-595, 1986.
Wong, D.F., Wagner, H.N., Jr., Tune,
L.E., Dannals, R.F., Pearlson, G.D., Links, J.M., Tamminga, C.A.,Broussolle,
E.P., Ravert, H.T., Wilson, A.A., Thomas Toung, J.K., Malat, J., Williams,
J.A., O'Tuama, L.A. Snyder, S.H., Kuhar, M.J., and Gjedde, A. Positron
Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive
Schizophrenics. Science 234: 1558-1563, 1986.
Ritz, M.C., Lamb, R.J., Goldberg S.R.,
and Kuhar, M.J. Cocaine Receptors on Dopamine Transporters are Related
to Self-administration of Cocaine. Science 237: 1219-1223, 1987.
Grigoriadis, D.E., Wilson, A.A., Lew,
R., Sharkey, J.S., and Kuhar, M.J. Dopamine Transport Sites Selectively
Labeled by a Novel Photoaffinity Probe: 125I-DEEP. J. Neurosci. 9(8):
2664-2670, 1989.
Kuhar, M.J., Sanchez-Roa, P.M., Wong,
D.F., Dannals, R.F., Grigoriadis, D.E., Lew, R., and Milberger, M. Dopamine
Transporter: Biochemistry, Pharmacology and Imaging. Eur. Neurol. 30(1):
15-20, 1990.
Carroll, F.I., Lewin, A.H., Philip, A.,
Parham, K., Boja, J.W., and Kuhar, M.J. Synthesis and Ligand Binding
of Cocaine Isomers at the Cocaine Receptor. J. Med. Chem. 34: 883-886,
1991.
Kuhar, M.J., Lloyd, D.G., and Loats,
H.L. Imaging Receptors by Autoradiography: Computer-Assisted Approaches.
J. Chem. Neuroanat. 4: 319-327, 1991.
Volkow, N.D., Gatley, S.J. Fowler, J.S.,
Chen, R., Logan, J., Dewey, S.L., Ding, Y.-S., Pappas, N., King, P.,
MacGregor, R.R., Kuhar, M.J., Carroll, F.I. and Wolf, A.P. Long-Lasting
Inhibition of in vivo Cocaine Binding to Dopamine Transporters by 3(-(4-Iodophenyl)Tropane-2-Carboxylic
Acid Methyl Ester: RTI-55 or (CIT. Synapse 19(3): 206-211, 1995.
Ding. Y.-S., Gatley, S.J., Fowler, J.S.,
Volkow, N.D., Aggarwal, D., Logan, J., Dewey, S.L., Liang, F., Carroll,
F.I. and Kuhar, M.J. Mapping Nicotinic Acetylcholine Receptors with
PET. Synapse 24: 403-407, 1996.
Wong, D.F., Harris, J.C., Naidu, S.,
Yokoi, F., Marenco, S., Dannals, R.F., Ravert, H.T., Yaster, M., Evans,
A., Rousset, O., Bryan, R.N., Gjedde, A., Kuhar, M.J. and Breese, G.R.
Dopamine Transporters are Markedly Reduced in Lesch-Nyhan Disease in
vivo. Proc. Natl. Acad. Sci. USA 93: 5539-5543, 1996.
Nirenberg, M.J., Chan, J., Pohorille,
A., Vaughan, R.A., Uhl, G.R., Kuhar, M.J. and Pickel, V.M. The Dopamine
Transporter: Comparative Ultrastructure of Dopaminergic Axons in Limbic
and Motor Compartments of the Nucleus Accumbens. J. Neurosci. 17: 6899-6907,
1997.
Koylu, E.O., Couceyro, P.R., Lambert,
P.D., Ling, N.C., DeSouza, E.B., and Kuhar, M.J. Immunohistochemical
Localization of Novel CART Peptides in Rat Hypothalamus, Pituitary and
Adrenal Gland. J. Neuroendocrinol. 9: 823-833, 1997.
Molina, P.E., Ding, Y.-S., Carroll, F.I.,
Liang, F., Volkow, N.D., Pappas, N., Kuhar, M., Abumrad, N., Gatley,
S.J., and Fowler, J.S. Fluoro-norchloroepibatidine: Preclinical Assessment
of Acute Toxicity. Nucl. Med. Biol. 24:743-747, 1997.
Lambert, P.D., Couceyro, P.R., McGirr,
K.M., Dall Vechia, S.E., Smith, Y., and Kuhar, M.J. CART Peptides in
the Central Control of Feeding and Interactions with Neuropeptide Y.
Synapse 29: 293-298, 1998.
Kuhar, M. Neurotransmitter Transporters
are NOT in the Synapse? Presented at INABIS '98 - 5th Internet World
Congress on Biomedical Sciences at McMaster University, Canada, December
7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/simantov/kuhar0153/two.html,
1998.
Broberger, C., Holmberg, K., Kuhar, M.J.,
and Hökfelt, T. Cocaine- and Amphetamine-Regulated Transcript in the
Rat Vagus Nerve: A Putative Mediator of Cholecystokinin-Induced Satiety.
Proc. Natl. Acad. Sci. USA 96: 13506-13511, 1999.
Dall Vechia-Adams, S., Smith, Y., and
Kuhar, M.J. CART Peptide-Immunoreactive Projection from the Nucleus
Accumbens Targets Substantia Nigra Pars Reticulata Neurons in the Rat.
J. Comp. Neurol. 434: 29-39, 2001.
Kuhar, M.J., Carroll, F.I., Bharat, N.,
and Landry, D.W. Anticocaine Catalytic Antibodies Have No Affinity for
RTI Compounds: Implications for Treatment. Synapse 41: 176-178, 2001.
Kuhar, M.J. and Joyce, A.R. Slow Onset
of CNS Drugs: Can Changes in Protein Concentration Account for the Delay?
Trends Pharmacol. Sci. 22: 450-456, 2001.
Jaworski, J.N., Kozel, M.A., Philpot,
K.B., and Kuhar M.J. Intra-accumbal Injection of CART (Cocaine-Amphetamine
Regulated Transcript) Peptide Reduces Cocaine-Induced Locomotor Activity.
J. Pharmacol. Exp. Ther. 307: 1038-1044, 2003.
Dominguez, G., del Giudice, E.M., and
Kuhar, M.J. CART Peptide Levels are Altered by a Mutation Associated
with Obesity at Codon 34. Mol. Psychiatry 9: 1065-1066, 2004.
Vicentic, A., Lakatos, A., and Kuhar,
M.J. CART (Cocaine- and Amphetamine-Regulated Transcript) Peptide Receptors:
Specific Binding in AtT20 Cells. Eur. J. Pharm. 528: 188-189, 2005.
Philpot, K.B., Dallvechia-Adams, S.,
Smith, Y., and Kuhar, M.J. A Cocaine-and Amphetamine-Regulated-Transcript
Peptide Projection from the Lateral Hypothalamus to the Ventral Tegmental
Area. Neuroscience 135: 915-925, 2005.
Vicentic, A., Francis, D., Moffett, M.,
Lakatos, A., Rogge, G., Hubert, G.W., Harley, J., and Kuhar, M.J. Maternal
Separation Alters Serotonergic Transporer Densities and Serotonergic
1A Receptors in Rat Brain. Neuroscience 140: 355-365, 2006.
Moffett, M.C., Harley, J., Francis, D.,
Sanghani, S.P., Davis, W.I., and Kuhar, M.J. Maternal Separation and
Handling Affects Cocaine Self-administration in Both the Treated Pups
as Adult and the Dams. J. Pharmaol. Exp. Ther. 317: 1210-1218, 2006.
Jones, DC and Kuhar, MJ. Cocaine-amphetamine-regulated
transcript expression in the rat nucleus accumbens is regulated by adenylyl
cyclase and the cyclic adenosine 5'-monophosphate/protein kinase a second
messenger system. J Pharmacol Exp Ther. 2006 Apr;317(1):454-61.
PMID 16322355.
Carroll, F.I., Howard, J.L., Howell,
L.L., Fox, B.S., and Kuhar, M.J. Development of the Dopamine Transporter
Selective RTI-336 as a Pharmacotherapy for Cocaine Abuse. AAPS J.
8: E196-E203, 2006.
Jones DC, Kuhar MJ. CART receptor binding in primary cell
cultures of the rat nucleus accumbens. Synapse. Feb;62(2):122-7. 2008.
PMID 18000808.
Jaworski JN, Hansen ST, Kuhar MJ, Mark
GP. Injection of CART peptide into the nucleus accumbens reduces
cocaine self-administration in the rat. Behav Brain Res 2008 191:266-271.
PMID: 18485497.
Hubert GW and Kuhar MJ. Cocaine administration
increases the fraction of CART cells in the rat nucleus
accumbens that co-immunostain for c-Fos. Neuropeptides
42:339-43, 2008. PMID18314190.
Rogge, G., Jones, D., Hubert, G.W., Lin,
Y. CART peptides: regulators of body weight, reward and other
functions. Nat Rev Neurosci, 2008 9(10):747-58. PMID: 18802445.
Kuhar, M.J. On Blacklisting in
Science. Sci Eng Ethics 14:301-303, 2008. PMID 18668347
Rogge GA, Jones DC, Green T, Nestler E, and Kuhar
MJ. Regulation of CART peptide expression by CREB in
the rat nucleus accumbens in vivo. Brain Res 1251:42-52,
2009. PMID 19046951.
Back
to top
|