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	Funding Current Funding "Metabotropic Glutamate Receptors: Novel Targets for Parkinson's Disease Pharmacotherapy" Principal Investigator: Yoland Smith, PhD Agency: National Parkinson Foundation Mega Grant Project Period: 7/01/2006-6/30/2008 The goal of this project is to test the antiparkinsonian effects and neuroprotective properties of mGluR5 antagonists against MPTP-induced degeneration of midbrain dopaminergic neurons in monkeys. "The thalamostriatal system:A potential target for Tourette Syndrome" Principal Investigator: Yoland Smith, PhD Agency: Tourette Syndrome Association Project Period: 6/01/2006-5/30/2007 The goal of this project is to understand the electrophysiological anatomical and neurochemical changes induced in the basal ganglia circuitry following high frequency stimulation of the thalamostriatal system in monkeys. "Metabotropic Glutamate Receptors in the Basal Ganglia" Principal Investigator: Yoland Smith, PhD Agency: National Institutes of Health-NINDS Type: R01 (NS037423-06A1) Project Period: 9/01/2003-8/30/2007 The goal of this project is to characterize the subcellular and subsynaptic localization of Homer proteins in the primate basal ganglia and study their role in trafficking of metabotropic glutamate receptors. "The thalamostriatal System in Primates" Principal Investigator: Yoland Smith, PhD Agency: National Institutes of Health-NINDS Type: R01 (NS2R01037948) Project Period: 4/01/2006-3/31/2010 The goal of this project is to elucidate various aspects of the synaptology and plasticity of the thalamostriatal system in normal and MPTP-treated parkinsonian monkeys. "GABA-B Receptors and Parkinson’s Disease" Principal Investigator: Yoland Smith, PhD Agency: National Institute on Neurological Disorders and Stroke, NIH Type: R01 (NS42937-01) Project Period: 7/01/2006-6/30/2011 This project aims at characterizing the localization and role of GABA-B receptors in the pre-synaptic modulation of glutamate release in primate basal ganglia. We also propose to test GABA-B agonists as potential therapeutic agents in parkinsonian monkeys. "Training in Systems and Integrative Biology: Neuroscience" Primary Investigator: Yoland Smith, PhD Agency: NIH/NIGMS Type: T32 (GM08605) Project Period: 7/01/2006-6/30/2011 This is the training grant for the PhD neuroscience program at Emory University. This grant provides financial support and covers tuition fees for six students in the program. "Metabotropic Glutamate Receptors in the Basal Ganglia " Principal Investigator: P. Jeffrey Conn, PhD Agency: National Institute of Health-NINDS Type R01 (NS048334) Project period: 12/01/2004-11/30/2009 This project aims at elucidating the roles of group III mGluRs in regulating inhibitory synaptic transmission in basal ganglia output nuclei. "Functions of Dopamine in the Susbstantia Nigra" Principal Investigator: Thomas Wichmann, MD Agency: National Institutes of Health-NINDS Type R01 (NS 049474-01) Project period: 7/01/2005-6/30/2010 The goal of this project is to elucidate the localization and functions of D1 and D2 receptors in regulating neurotransmission in the substantia nigra of normal and parkinsonian monkeys. top of page

Funding

Current Funding

"Metabotropic Glutamate Receptors: Novel Targets for Parkinson's Disease Pharmacotherapy"
Principal Investigator: Yoland Smith, PhD
Agency: National Parkinson Foundation
Mega Grant
Project Period: 7/01/2006-6/30/2008
The goal of this project is to test the antiparkinsonian effects and neuroprotective properties of mGluR5 antagonists against MPTP-induced degeneration of midbrain dopaminergic neurons in monkeys.

"The thalamostriatal system:A potential target for Tourette Syndrome"
Principal Investigator: Yoland Smith, PhD
Agency: Tourette Syndrome Association
Project Period: 6/01/2006-5/30/2007
The goal of this project is to understand the electrophysiological anatomical and neurochemical changes induced in the basal ganglia circuitry following high frequency stimulation of the thalamostriatal system in monkeys.

"Metabotropic Glutamate Receptors in the Basal Ganglia"
Principal Investigator: Yoland Smith, PhD
Agency: National Institutes of Health-NINDS
Type: R01 (NS037423-06A1)
Project Period: 9/01/2003-8/30/2007
The goal of this project is to characterize the subcellular and subsynaptic localization of Homer proteins in the primate basal ganglia and study their role in trafficking of metabotropic glutamate receptors.

"The thalamostriatal System in Primates"
Principal Investigator: Yoland Smith, PhD
Agency: National Institutes of Health-NINDS
Type: R01 (NS2R01037948)
Project Period: 4/01/2006-3/31/2010
The goal of this project is to elucidate various aspects of the synaptology and plasticity of the thalamostriatal system in normal and MPTP-treated parkinsonian monkeys.

"GABA-B Receptors and Parkinson’s Disease"
Principal Investigator: Yoland Smith, PhD
Agency: National Institute on Neurological Disorders and Stroke, NIH
Type: R01 (NS42937-01)
Project Period: 7/01/2006-6/30/2011
This project aims at characterizing the localization and role of GABA-B receptors in the pre-synaptic modulation of glutamate release in primate basal ganglia. We also propose to test GABA-B agonists as potential therapeutic agents in parkinsonian monkeys.

"Training in Systems and Integrative Biology: Neuroscience"
Primary Investigator: Yoland Smith, PhD
Agency: NIH/NIGMS
Type: T32 (GM08605)
Project Period: 7/01/2006-6/30/2011
This is the training grant for the PhD neuroscience program at Emory University. This grant provides financial support and covers tuition fees for six students in the program.

"Metabotropic Glutamate Receptors in the Basal Ganglia "
Principal Investigator: P. Jeffrey Conn, PhD
Agency: National Institute of Health-NINDS
Type R01 (NS048334)
Project period: 12/01/2004-11/30/2009
This project aims at elucidating the roles of group III mGluRs in regulating inhibitory synaptic transmission in basal ganglia output nuclei.

"Functions of Dopamine in the Susbstantia Nigra"
Principal Investigator: Thomas Wichmann, MD
Agency: National Institutes of Health-NINDS
Type R01 (NS 049474-01)
Project period: 7/01/2005-6/30/2010
The goal of this project is to elucidate the localization and functions of D1 and D2 receptors in regulating neurotransmission in the substantia nigra of normal and parkinsonian monkeys.

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