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Current Funding

"Plasticity of striatal glutamatergic synapses in Parkinson's disease"
Principal Investigator: Yoland Smith, PhD
Agency: NIH/NINDS
Type: R01 (NS037948-14)
Project Period:2/01/2010-1/31/2014
The goal of this project is to elucidate various aspects of the synaptology and plasticity of the thalamostriatal system in normal and MPTP-treated parkinsonian monkeys.

"GABA-B Receptors and Parkinson's Disease"
Principal Investigator: Yoland Smith, PhD
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Agency: NIH/NINDS
Type: R01 (NS42937)
Project Period: 4/01/2007-3/31/2012
This project aims at characterizing the localization and role of GABA-B receptors in the pre-synaptic modulation of glutamate release in primate basal ganglia. We also propose to test GABA-B agonists as potential therapeutic agents in parkinsonian monkeys"

"Training in Systems and Integrative Biology: Neuroscience"
Principal Investigator: Yoland Smith, PhD
Agency: NIH/NIGMS
Type: T32 GM08605-10
Project Period: 7/01/2006-6/30/2011
This is the training grant for the PhD neuroscience program at Emory University. This grant provides financial support and covers tuition fees for six students in the program.

"Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy"
Principal Investigator: Yoland Smith, PhD
Agency: NIH/NINDS
Type: P50NS071669-01
Project Period: 7/1/2010-6/30/2015

"Extrastriatal Functions of Dopamine"
Principal Investigator: Thomas Wichmann, PhD
Agency: NIH/NINDS
Type: R01Ns071074-01
Project Period: 5/1/2010-4/30/2015

"MGluR4 as therapeutic targets in Parkinson's disease"
Principal Investigator: Yoland Smith, PhD
Agency: RJG Foundation
Project Period: 11/01/2008-10/31/2011
This project aims at testing the antiparkinsonian and electrophysiological effects of local administration of mGluR4 agonists in the striatum and globus pallidus of MPTP-treated parkinsonian monkeys.

"Early Cognitive Impairment in Parkinson's disease"
Principal Investigator: Yoland Smith, PhD
Agency: NCRR (Support of Yerkes National Primate Center Supplement)
Project Period: 11/01/2008-10/30/2010

money roll image"Thalamostriatal system in Parkinsonism"
Principal Investigator: Thomas Wichmann, PhD
Agency: NIH/NINDS
Type: RO1 NS062876
Project Period: 4/01/2009-3/31/2012

The goal of this project is to elucidate the role of the thalamostriatal system in regulating activity of cholinergic interneurons and projection neurons in normal and parkinsonian monkeys.

"Biomarkers for preclinical Parkinson's disease"
Principal Investigator: Jing Zhang, PhD
Agency: NIH/NINDS
Type: R01 NS057567
Project Period: 7/01/2008-10/31/2010
The goal of this project is to identify pre-clinical biomarkers for Parkinson's disease.

"PDZ scaffold regulation of astrocytic glutamate receptors and transporters"
Principal Investigator: Randy Hall, PhD
Agency: NIH/NINDS
Tpye: R01 NS055179
Project Period: 4/01/2008-3/31/2013
The goal of this project is to characterize the localization and function of various PDZ scaffold proteins in regulating astrocytic glutamate receptors and transporters.

"Mechanisms of Endosome Trafficking in Neurons"
Principal Investigator: Victor Faundez, PhD
Agency:NIH/NINDS
Type: R01 Ns042599
Project Period: 9/01/2008-8/31/2013
The goal of this proposal is to understand the protein interactions regulating endosome trafficking in neurons.

"Discovery of mGluR4 potentiators for symptomatic and disease-modifying treatment of PD"
Principal Investigator: Conn-Smith
Agency: Michael J Fox Foundation
Project Period: 12/1/2010-11/30/2011

"Evaluation of Prosavin for providing efficacy to MPTP lesioned rhesus monkeys"
Contract with Oxford Biomedical
Project Period: 4/23/2008-12/31/2010