Course Agenda (June 24, June 28, 2013)
Check-in will begin at 8:45 am on Monday , June 24, 2013. E363 Emerson Hall , Emory University. The course will be taught from 9:00 am — 11:45 am. Hands-on experiments will start at 1:00 pm in NMR labs. 213. 142. Problem sets will be distributed at the course and time will be allowed for students to determine structures and spectral assignments. A book of experiment instruction will be distributed at the experiment sessions. Each student has opportunity to setup experiments with instructors. Students will be assigned an “unknown sample” to acquire NMR data and determine the structure during the course. If the student meets all course requirements and complete the assignments, a certificate and an NMR mug will be awarded.
Lecture One (9:00 am - 11:45 am, June 24, 2013 ) Basic concepts in FT-NMR and advanced 1D NMR methods. Introduction of NMR spectrometers, hardware and software. Experiment One (1:00 pm – 6:00 pm, in RM 213) 1D proton, carbon-13 NMR experiments with gated and off resonance 1H decoupling and APT, DEPT 1D NOE etc.
Lecture Two (9:00 am - 11:45 am, June 25) Basic concepts in FT-NMR and advanced 2D NMR methods. NMR hardware and software, probe calibration, shimming. Experiment Two: (1:00 pm – 6:00 pm) Instrument calibration for advanced 2D NMR experiments. Gradient Shimming, probe tuning, 90 degree pulses, temperature calibration etc.
Lecture Three (9:00 am - 11:45 am, June 26) Principles of 2D-NMR; Most useful 2D-NMR: COSY, HETCOR, NOESY, ROESY, TOCSY. Experiment Three: (1:00 pm – 6:00 pm) COSY and HETCOR experiments and processing. Other 2D experiments can be arranged with attendee’s request.
Lecture Four (9:00 am - 11:45 am, June 27) 2D HMQC experiments and applications; 2D data Processing with different weighting functions. Experiment Four (1:00 pm – 6:00 pm) Data processing: COSY, HETCOR acquired in Experiment Three and other popular 2D-NMR spectra such as phase sensitive NOESY, DQCOSY and TOCSY. Special experiments training requested by attendees. (Gradient Shimming techniques, Diffusion studies by NMR techniques, 19F decoupling, other nuclei such as 51V, 27Al, 31P, 15N, 183W, 17O, 2H, 39K, 29Si and 11B etc. High/Low temperature experiments.
Lecture Five ( 9 am - 11:45 am, June 28) Introduction to Solid State NMR; Special NMR techniques such as T1, T2 measurements, CPMAS, TOSS and REDOR, exchange NMR, High/low temperature NMR, diffusion measurements etc. Questions and Answers. Experiment Five (1:00 pm – 6:00 pm) More advanced NMR experiments on Solid State NMR, INOVA600 and UNITY600 will be arranged upon request. All unknown sample structures due at noon.Pizza Party in Room 410, Emerson at Noon.
1. 1D and 2D NMR Experiment Methods. By Shaoxiong Wu
2. High Resolution NMR Techniques in Organic Chemistry by Timothy D. W. Claridge
3. Instructions of NMR Experiments. By Shaoxiong Wu and Bing Wang