Thrombolysis for Acute Pulmonary Embolism

1/16/2002 (Somerset)

Question:  What are the indications for use of  thrombolytic therapy in patients with acute presentation of PE?

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Unique Identifier: 99304915 / PMID: 10378570

Authors: Arcasoy SM. Kreit JW. Institution Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, USA. arcasoy@mail.med.upenn.edu

Title: Thrombolytic therapy of pulmonary embolism: a comprehensive review of current evidence. [Review] [102 refs]

Source: Chest. 115(6):1695-707, 1999 Jun.

Abstract: Pulmonary embolism (PE) is a common disorder that is accompanied by significant morbidity and mortality. Although anticoagulation is the standard treatment for PE, thrombolytic therapy, with its ability to produce rapid clot lysis, has long been considered an attractive alternative. Although many studies have been performed over the past three decades, however, the indications for the use of thrombolytic agents in patients with PE remain controversial. In this article, we review the medical literature and provide evidence-based guidelines for the use of thrombolytic therapy. We will also discuss the practical aspects of PE thrombolysis. [References: 102]