Syndrome of Inappropriate Antidiuretic Hormone (SIADH) - Idiopathic or Unknown Origin

7/01/02

Question: What is the incidence of, and chances of reurrence for, idiopathic SIADH?

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Unique Identifier:9915284

Authors: Sterns RH.

Institution: Department of Medicine, Rochester General Hospital, NY 14621, USA. rsterns@viahealth.org

Title: The syndrome of inappropriate antidiuretic hormone secretion of unknown origin.

Source: American Journal of Kidney Diseases [Online]. 33(1):161-3; discussion 163-5, 1999 Jan.

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Unique Identifier:6771455

Authors: Anonymous.

Title: Inappropriate antidiuretic hormone secretion of unknown origin.

Source: Kidney International. 17(4):554-67, 1980 Apr.

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Unique Identifier:474598

Authors: Whitaker MD. McArthur RG. Corenblum B. Davidman M. Haslam RH.

Title: Idiopathic, sustained, inappropriate secretion of ADH with associated hypertension and thirst.

Source: American Journal of Medicine. 67(3):511-5, 1979 Sep.

Abstract: A 15 year old girl presented with excessive thirst and hypertension (170/110 mm Hg). Biochemical investigations revealed serum sodium 118 meq/liter, serum osmolality 238 mosmol/liter, urine sodium 90 meq/liter, urine osmolality 700 mosmol/liter, persistenly elevated serum antidiuretic hormone (ADH) levels (5.8 to 11.9 pg/ml) and no obvious cause for the hypertension. The hypertension is, at least in part, volume-related, diminishing with fluid restriction. Features of gross water intoxication (e.g., confusion, coma) have not occurred. The etiology of the inappropriate secretion of ADH is not obvious but is not thought to be due to "resetting of osmoreceptors" as evidenced by failure to maximally dilute urine following a water load test and persistently elevated serum ADH levels. A similar patient described by Epstein and associates in 1962 is presently well with persistent features of inappropriate secretion of ADH. CAS Registry/EC Number 52-39-1 (Aldosterone). 7440-23-5 (Sodium).

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