Emphysatemous Cystitis

10/09/2002

Question: What factors can predispose to complicated urinary tract infections?

Link Directly to Fulltext Article at Science Direct

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Unique Identifier:12113874

Authors: Stapleton A.

Institution: Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle 98195, USA.

Title: Urinary tract infections in patients with diabetes. [Review] [41 refs]

Source: American Journal of Medicine. 113 Suppl 1A:80S-84S, 2002 Jul 8.

Abstract: Results of various epidemiologic studies suggest that bacteriuria and urinary tract infection (UTI) occur more commonly in women with diabetes than in women without this disease. Similar findings have been demonstrated for asymptomatic bacteriuria (ASB), with ASB being a risk factor for pyelonephritis and subsequent decline in renal function. Although ASB is not associated with serious health outcomes in healthy patients, further research needs to be undertaken regarding the impact of ASB in patients with diabetes.Patients with diabetes often have increased complications of UTI, including such rare complications as emphysematous cystitis and pyelonephritis, fungal infections (particularly Candida species), and increased severity and unusual manifestations (e.g., gram-negative pathogens other than Escherichia coli).Anatomic and functional abnormalities of the urinary tract are also associated with diabetes. Such abnormalities result in greater instrumentation of the urinary tract, thereby increasing the risk of secondary UTI. In addition, these abnormalities complicate UTI and require specialized treatment strategies. There is a greater likelihood of UTI affected by antimicrobial resistance or atypical uropathogens, and the risk of upper tract involvement is increased. Pre- and posttherapy urine cultures are therefore indicated.The initial choice of empiric antimicrobial therapy should be based on Gram stain and urine culture. Choice of antibiotic therapy should integrate local sensitivity patterns of the infecting organism. Fluoroquinolones are a reasonable empiric choice for many patients with diabetes. For seriously ill patients, including patients infected with Pseudomonas spp., such agents as imipenem, ticarcillin-clavulanate, and piperacillin-tazobactam may also be considered. Treatment of ASB in patients with diabetes is often recommended to prevent the risk of symptomatic UTI. However, the management of ASB in patients with diabetes is complex, with no single preferred approach. [References: 41] CAS Registry/EC Number 0 (Anti-Infective Agents, Urinary).

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Unique Identifier:2321826

Authors: Ankel F. Wolfson AB. Stapczynski JS.

Institution: University of Wisconsin School of Medicine, Milwaukee.

Title: Emphysematous cystitis: a complication of urinary tract infection occurring predominantly in diabetic women.

Source: Annals of Emergency Medicine. 19(4):404-6, 1990 Apr.

Abstract: The case of a patient with emphysematous cystitis who presented with complaints of lower abdominal pain, dysuria, and pneumaturia is presented. The presenting symptoms, differential diagnosis, and radiographic and cystoscopic appearances of emphysematous cystitis, a rare complication of lower urinary tract infection occurring almost exclusively in diabetics, are reviewed. Treatment consists of urinary drainage, prompt initiation of antibiotic therapy, and strict glucose control. The prognosis usually is excellent.

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