Chronic Untreated (Asymptomatic or Painless) Gout

3/18/2005

Question: What are aspects of chronic, untreated, painless, or asymptomatic gout?

 <4>

Unique Identifier:10386113

Authors: Jones RE. Ball EV.

Institution: Division of Clinical Immunology, University of Alabama School of Medicine, Birmingham, USA.

Title: Gout: beyond the stereotype.

Source: Hospital Practice (Office Edition). 34(6):95-102; discussion 102-3; quiz 133, 1999 Jun 15.

Abstract: Not all gout presents with involvement of the big toe, and not all gout patients are middle-aged men. Chronic gout may mimic rheumatoid arthritis; hyperuricemia may develop in postmenopausal women and in organ transplant recipients who are being treated with immunosuppressive agents. Both classic and nonclassic cases may benefit from new therapeutic agents. CAS Registry/EC Number/Name of Substance 0 (Gout Suppressants). 114798-26-4 (Losartan). 2465-59-0 (Oxypurinol). 315-30-0 (Allopurinol). EC 1-7-3-3 (Urate Oxidase).

<6>

Unique Identifier:3053335

Authors: Campbell SM.

Institution: Division of Arthritis and Rheumatic Diseases, Oregon Health Sciences University.

Title: Gout: how presentation, diagnosis, and treatment differ in the elderly. [Review] [20 refs]

Source: Geriatrics. 43(11):71-7, 1988 Nov.

Abstract: Although frequently a typical acute monoarticular arthritis, gout in the elderly is often a chronic, polyarticular disease, sometimes with minimal inflammation. It can be associated with osteoarthritis and diuretic therapy, can follow minor trauma or medical illness, and is seen commonly in women. The management of gout in the elderly requires special consideration of the expected course of the disease and of the risks of medical therapy. [References: 20]

<7>

Unique Identifier:3686156

Authors: Scopelitis E. McGrath H Jr.

Institution: Department of Medicine, Louisiana State University School of Medicine, New Orleans.

Title: NSAID-masked gout.

Source: Southern Medical Journal. 80(11):1464-5, 1987 Nov.

Abstract: The use of NSAIDs masked the diagnosis of gout in nine patients with the chronic polyarticular form of the disease. The escape from detection of chronic polyarticular gout resulted in a needless dependence on NSAIDs, failure to correct the metabolic problem, and in some cases progression of joint destruction. Although acute inflammation was modified, basic pathogenic mechanisms remained unchecked and joint disease continued. The indiscriminate use of NSAIDs may, by promoting misdiagnosis, become a major obstacle to effective control of this, perhaps the most remediable of arthritic disorders.
 

<8>

Unique Identifier:3953333

Authors: Schousboe JT. Davey K. Gilchrist NL. Sainsbury R.

Title: Chronic polyarticular gout in the elderly: a report of six cases.

Source: Age & Ageing. 15(1):8-16, 1986 Jan.

Abstract: This report describes six elderly patients with previously undiagnosed and untreated chronic polyarticular gout, five of whom were seen at a Geriatric Rehabilitation and Assessment Unit within a 3-month period. All were on long-term diuretic therapy. Four patients had coexisting osteoarthritis. Three patients were unable to recall any prior history of attacks of acute arthritis and four patients were significantly disabled from gout. Chronic polyarticular gout in these patients was previously misdiagnosed and inadequately treated, resulting in otherwise preventable disability. CAS Registry/EC Number/Name of Substance 0 (Gout Suppressants).