Volume 5, Number 34; April 26, 2006
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Volume 5, Number 34; April 26, 2006 |
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62-year-old female found unresponsive.
Recommended reading:
Integrated PET/CT: current applications and future directions.
PET/CT scanner instrumentation, challenges, and solutions. [Use search term: 15488555 ]
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Patient: 62 year old female found unresponsive by family members; high calcium (17) led to workup for cancer; all tests including whole body CT were negative, PET scan eventually discovered renal cell carcinoma. |
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Session Handout:
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Clinical Question: 1) What are the operational characteristics of the PET scan?
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Readings:
Link Directly to Fulltext Article at Publisher <1> Unique Identifier [PMID]: 16436809 Authors: von Schulthess GK. Steinert HC. Hany TF. Institution: Department of Nuclear Medicine, University Hospital of Zurich, Raemistrasse 100, CH-8091 Zurich, Switzerland. Title: Integrated PET/CT: current applications and future directions. [Review] [82 refs]
Source: Radiology. 238(2):405-22, 2006 Feb. Abstract: For the past 5 years, combined positron emission tomography (PET) and computed tomography (CT), or PET/CT, has grown because the PET portion provides information that is very different from that obtainable with other imaging modalities. However, the paucity of anatomic landmarks on PET images makes a consistent "hardware fusion" to anatomic cross-sectional data extremely useful. Clinical experience indicates a single direction: Addition of CT to PET improves specificity foremost, but also sensitivity, and the addition of PET to CT adds sensitivity and specificity in tumor imaging. Thus, PET/CT is a more accurate test than either of its individual components and is probably also better than side-by-side viewing of images from both modalities. The synergistic advantage of adding CT is that the attenuation correction needed for PET can also be derived from the CT data, an advantage not obtainable by integrating PET and magnetic resonance imaging. This makes PET/CT 25%-30% faster than PET alone with standard attenuation-correction methods, leading to higher patient throughput and a more comfortable examination, which typically last 30 minutes or less. Fluorodeoxyglucose (FDG) PET/CT appears to provide relevant information in the staging and therapy monitoring of many tumors, including lung carcinoma, mesothelioma, colorectal cancer, lymphoma, melanoma, and many others, with the notable exception of prostatic cancer. For prostatic cancer, choline derivatives may become useful radiopharmaceuticals. The published literature on the applications of FDG PET/CT in oncology is still limited, but several well-designed studies have demonstrated the benefits of PET/CT. (c) RSNA, 2006 [References: 82] Publication Type: Journal Article. Review.
Fulltext Available in MDConsult using Journal Search and the search term: 15488555 <2> Unique Identifier [PMID]: 15488555 Authors: Alessio AM. Kinahan PE. Cheng PM. Vesselle H. Karp JS. Institution: Department of Radiology, University of Washington, 1959 NE Pacific Street, Box 356004, Seattle, WA 98195-6004, USA. Title: PET/CT scanner instrumentation, challenges, and solutions. [Review] [63 refs]
Source: Radiologic Clinics of North America. 42(6):1017-32, vii, 2004 Nov. Abstract: PET/CT scanners offer a hardware solution for aligning and viewing functional and anatomic images that is immune to many of the errors in strictly software registration techniques. Moreover, PET attenuation-corrected emission scans benefit from the use of the onboard CT for fast, low-noise attenuation correction. Along with the significant improved localization and reduced acquisition time, PET/CT scanners also introduce new instrumentation challenges ranging from patient movement to quantitative attenuation correction. This article provides an overview of current PET/CT scanner technology, a discussion of challenges faced by these systems, and pending solutions. [References: 63] Publication Type: Journal Article. Review.
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Resident Report / Department of Medicine & Grady Branch Library Emory University School of Medicine 2005 Edition Participating Faculty: Carlos Del Rio MD / Joyce Doyle MD / Lorenzo Difrancesco MD / Erich Folch MD / Alicia Hidron MD
Contact:
Karl Woodworth
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